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Objective To evaluate the efficacy of percutaneous drug penetration in the treatment of young patients with relapsed positive pulmonary tuberculosis. Methods From June 2013 to May 2016,eighty-four cases of with relapsed bacterias and pulmonary tuberculosis treated in Hebei Chest Hospital were enrolled in the study and were randomly divided into the observation group and the control group, 42 cases in each group. Both groups were treated with conventional anti tuberculosis drug 2HRZES/6HRE, the patients in the observation group were treated with ultrasound conductometric instrument and ultrasound conductive gel patch (isoniazid 0. 1 g) for 1 time /d,20 min each time. The course lasted for 3 months. Results At the end of 1,3 and 8 months treatment,the rates of sputum negative conversion in the observation group were 45. 24%( 19/42),66. 07%( 28/42), 92. 86%( 39/42), which were significantly higher than those of the control group ((23. 81%( 10/42), 40. 48%( 17/42), 73. 81%( 31/42 )), the difference between the two groups was statistically significant (x 2＝4. 27,5. 79,5. 49,P＜0. 05). At the end of the 8 months,the obvious absorption rate of the lesion was 94. 48%(38/42),and the control group was 69. 05%(29/42). The difference between the two groups was statistically significant (x 2＝5. 97,P＜0. 05). At the end of 8 months,the curative rate of the observation group was 90. 48%, while that of the control group was 64. 29%. The difference between the two groups was statistically significant (x 2＝5. 97,P＜0. 05). Conclusion Percutaneous drug penetration has good safety. Combined with systemic chemotherapy,it can improve the treatment effect of young patients with relapsed bacterias positive pulmonary tuberculosis,and is worthy of promotion.
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Objective To investigate the clinical value of Xpert M TB/RIF in the early diagnosis of tuberculous meningitis (TBM ) .Methods Totally 130 patients with central nervous system infection in our hospital from February 2015 to December 2016 were divided into two groups ,65 cases of TBM patients as the TBM group ,65 cases of non TBM patients as the non TBM group . The CSF samples of all patients were respectively detected by acid fast staining ,Roche solid culture and Xpert MTB/RIF assay .The test results were compared .Results With clinical diagnosis as the gold standard ,the sensitivity of Xpert MTB/RIF to detection of TBM was 43 .08% and specificity was 100 .00% .The sensitivity of solid culture to detection of TBM was 58 .46% and specificity was 98 .46% .The sensitivity of acid fast staining to detection of TBM was 9 .23% and specificity was 100 .00% .Based on the re-sults of drug sensitivity test of traditional proportional method ,the sensitivity of Xpert M TB/RIF to detection of rifampin resistance was 88 .89% and specificity was 98 .35% .Conclusion Xpert M TB/RIF is a new diagnostic technique for detecting TBM and ri-fampin resistance in patients .It has the advantages of rapid ,direct ,reliable and high specificity and is worthy of clinical application .
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Objective To investigate the clinical value of Xpert M TB/RIF in the early diagnosis of tuberculous meningitis (TBM ) .Methods Totally 130 patients with central nervous system infection in our hospital from February 2015 to December 2016 were divided into two groups ,65 cases of TBM patients as the TBM group ,65 cases of non TBM patients as the non TBM group . The CSF samples of all patients were respectively detected by acid fast staining ,Roche solid culture and Xpert MTB/RIF assay .The test results were compared .Results With clinical diagnosis as the gold standard ,the sensitivity of Xpert MTB/RIF to detection of TBM was 43 .08% and specificity was 100 .00% .The sensitivity of solid culture to detection of TBM was 58 .46% and specificity was 98 .46% .The sensitivity of acid fast staining to detection of TBM was 9 .23% and specificity was 100 .00% .Based on the re-sults of drug sensitivity test of traditional proportional method ,the sensitivity of Xpert M TB/RIF to detection of rifampin resistance was 88 .89% and specificity was 98 .35% .Conclusion Xpert M TB/RIF is a new diagnostic technique for detecting TBM and ri-fampin resistance in patients .It has the advantages of rapid ,direct ,reliable and high specificity and is worthy of clinical application .
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Objective To evaluate whether the forced expiratory volume in sixth scend(FEV6) was the optimal surrogate for forced vital capacity (FVC) in the diagnosis for chronic obstructive pulmonary disease (COPD).Methods Retrospectively analyzed the spirometric data of 142 COPD patients (7 cases with mild COPD,60 cases with moderate COPD,48 cases with severe COPD,27 cases with extremely severe COPD) admitted to Hebei Chest Hospital from October 2011 to October 2012 who had FEV6 data.FEV6,FEV5,FEV4 and FEV3 were measured on volume-time curves and the diagnostic value was analyzed.Results FEV6,FEV5,FEV4 and FEV3 were highly correlated to FVC (r =0.994,0.939,0.935 and 0.923 respectively,P ＜0.001).Assuming =70％ as the diagnostic standard for obstruction,FEV1/FEV6 had a diagnostic rate of 92.96％ with a false negative rate of 7.04％.FEV1/FEV5,FEV1/FEV4 and FEV1/FEV3 had higher false negative rates (9.86％,13.38％ and 27.46％ respectively) than FEV6.The value of FEV1/FEV6-FEV1/FVC had no statistical significance between the mild-moderate and the severe-extremely severe COPD groups(t =1.376,P =0.171).Conclusion There is a strong correlation between FEV6 and FVC.FEV6 may be the best surrogate for FVC in the diagnosis of chronic obstructive pulmonary disease.Elevating diagnostic critical value can reduce the false negative rate.
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BACKGROUND: At the process of wound healing, the epithelial cells and epidermal stem cells interactions is complicated which promoting the mechanisms of wound healing. The abnormities of any fine phase can be result in delayed healing or scarring. OBJECTIVE: To summarize the characterization of epithelial cells and epidermal stem cells and their interaction in wound healing so that we can recognize the mechanisms of scarring from histomorphology, biochemistry and molecular variations. METHODS: A computer-based online search of Pubmed Database was undertaken to identify the relevant articles on epithelial cell and epidermal stem cells interactions in wound healing and results in scarring published from 1974 to 2009 with the key words of "epithelial cells, epithelial stem cells, wound healing, keratinocytes, fibroblasts, hypertrophic scar, keloid" in English. At the same time, Chinese relevant articles were searched in China Journal Full-text Database (CJFD) published between 1999 and 2009 with the same key words in Chinese. A total of 43 articles were collected about the cell structure (3 articles), the cell interactions in wound healing and scarring (16 articles), the relevant on epithelial stem cells (24 articles).RESULTS AND CONCLUSION: The effect of different cells in epithelial tissue is known to all. The keratinocytes and fibroblasts had been on studying frequently, and their closely correlated to scarring. At present, the epithelial stem cells has been confirmed, but the relevant on their location, quality and specific epidermal markers are unclear which need to study and explore. With the rapidly development of science and technology, we maybe control the expression of cells by genic regulation not only culture the cells of our need but to prevent the scarring.